Case Studies from VALIDOGEN

Case Studies – Applications of UNLOCK PICHIA® Technology


This section presents selected case studies that illustrate the application of VALIDOGEN’s UNLOCK PICHIA® technology in recombinant protein expression. The examples cover development of methanol-induced and methanol-free Pichia strains and processes, showing how the platform has been used to meet specific technical and regulatory requirements across different industries.

Case study III - methanol-induced bivalent VHH production in Pichia yielding 31 g/L

Scientist working on bioreactor cultivation setup for optimizing methanol-induced protein production using VALIDOGEN’s UNLOCK PICHIA® technology.

Case study II - Methanol-free VHH production for maximization of product titer

Close-up of a stainless steel bioreactor used in VALIDOGEN's fermentation process development laboratorys, with a scientist working in the background.

Case study I - Methanol-free VHH production for maximization of STY