Hand in blue glove holding a petri dish with a Pichia pastoris yeast culture in a biotechnology laboratory, VALIDOGEN

Case Studies from VALIDOGEN

Case Studies – Applications of UNLOCK PICHIA® Technology


This section presents selected case studies that illustrate the application of VALIDOGEN’s UNLOCK PICHIA® technology in recombinant protein expression. The examples cover development of methanol-induced and methanol-free Pichia strains and processes, showing how the platform has been used to meet specific technical and regulatory requirements across different industries.

High-throughput screening setup with stacks of microtiter plates in the foreground; two lab technicians in the background performing clone selection and Pichia strain evaluation.

Process-Relevant Clone Selection in a Typical Pichia pastoris Strain Development Workflow

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31 g/L Bivalent VHH by Methanol-Induced Pichia Production

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Scientist working on bioreactor cultivation setup for optimizing methanol-induced protein production using VALIDOGEN’s UNLOCK PICHIA® technology.

Maximizing Product Titer in Methanol-Free Production of Bivalent VHH in Pichia

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Close-up of a stainless steel bioreactor used in VALIDOGEN's fermentation process development laboratorys, with a scientist working in the background.

Maximizing Space-Time Yield in Methanol-Free Production of Bivalent VHH in Pichia

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