Pichia Protein Expression Services

UNLOCK PICHIA® - with manufacturability in mind

Customer-oriented protein expression services, optimized for the requirements of different industries

We offer lean expression feasibility studies assessing the expressibility of your protein including delivery of purified lab-scale protein samples. We generate high-performance Pichia pastoris production strains in competitive time frames, develop scalable bioreactor cultivation protocols, and undertake protein purification process development/optimization. Services are paired with technology transfer for smooth implementation of your protein production process at your facility or at your CMO.

With manufacturability in mind, VALIDOGEN is addressing today's protein manufacturing challenges by early consideration of production strain and process requirements. The individual needs of different industries including biopharma, food & feed, industrial biotechnology, and diagnostics are reflected in our customizable and flexible project setup. Clients from all industries can benefit from our powerful protein production technology platform and modular approach utilizing the most relevant UNLOCK PICHIA® tools for their protein of interest or their field of application.

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01 Fast and reliable answers

Expression Feasibility Studies

  • Fast assessment of expression feasibility and potential for further improvement
  • Immediate answers for a reliable go/no-go decision
  • Results from micro-scale screening transferable to bioreactor cultivation
  • Rapid generation of protein samples and protein production strains
02 Optimized yields & industrial production strains

Pichia Strain Development

  • Accelerated generation of high-performance expression strains optimized for the production of commercial protein products
  • Enhancement of production levels & product quality
  • Fast and straightforward production of non-GMP protein samples
  • Reduced downstream processing efforts due to low levels of secreted impurities
  • Full documentation of toolbox elements to simplify and support your regulatory filings
03 Robust & scalable fermentation and protein purification processes

Bioprocess Development

  • Boosted space-time yields through optimized VALIDOGEN cultivation protocols
  • Reduced manufacturing costs through improved cultivation processes
  • Scalable, robust, transferable, and cmc-ready manufacturing system
  • Intensified processes - high product titer and short cultivation time through VALIDOGEN's methanol-free cultivation system
  • Protein purification process development for a robust scalable downstream process
  • Full documentation to simplify and support your regulatory filings

FAQs - Working with VALIDOGEN

What is the benefit of working with VALIDOGEN?

When you work with VALIDOGEN, you work with a team of experts with more than 15 years of experience in Pichia pastoris strain and process development. Our focus is delivering robust, high-performing strains and processes that accelerate your protein development success.

What makes VALIDOGEN different from a standard protein expression service provider?

Unlike standard providers, everything we do is tailored to your project’s specific needs. By combining our UNLOCK PICHIA® platform with deep scientific expertise, we deliver customized solutions rather than one-size-fits-all services — ensuring the best chance of success for your protein. Our exclusive focus on Pichia pastoris further sets us apart, enabling us to apply unmatched depth of knowledge and optimization to every project.

Who benefits from VALIDOGEN’s services and technologies?

Our services are valuable for a wide range of organizations:

  • Biotech and pharma companies developing biopharmaceuticals.
  • Food and feed companies needing safe, methanol-free protein production.
  • Industrial biotech companies looking for efficient enzyme production.
  • Startups or academic spin-offs seeking proof-of-concept data to move to the next stage.

How does project initiation look like?

Projects typically begin with a discussion of your protein(s) and goals, followed by a tailored proposal outlining possible strategies, timelines, and deliverables. We aim to make the onboarding process clear, collaborative, and efficient.

How does VALIDOGEN de-risk manufacturability?

We optimize strains and processes for scalability, robustness, and reproducibility. A quick, low-cost feasibility study can also confirm early whether your protein will express successfully, helping to reduce risk before full-scale development.

What’s the easiest way to get started?

Simply reach out to us via our contact page. We’ll set up an initial conversation to understand your needs and explore how we can help.

OUR TEAM OF EXPERTS

Contact us to learn more about VALIDOGEN’s service portfolio

Iskandar Dib, PhD
Principal Scientist & Business Development Manager
Rosie Maddock, PhD
Business Development Manager

VALIDOGEN's expert team is happy to discuss your project requirements. Send any project related requests to project@validogen.com, directly to our scientists, or use our contact form.

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