VALIDOGEN Launches Next-Generation Synthetic Methanol-Free Promoters

We are excited to announce the launch of our next-generation synthetic methanol-free promoter library for recombinant protein production in Pichia pastoris.
These innovative new promoters expand the capabilities of our proprietary UNLOCK PICHIA® platform, and enable enhanced, controlled, inducer-free protein production with supernatant titers exceeding 20 g/L across multiple protein classes - achieved using just standard, non-optimized fermentation protocols. 

The new promoter library offers:  
• Increased productivities
• Tunable and time-controlled expression
• Reduced metabolic burden
• Simplified process control
• Lower oxygen demand and cooling requirements
• No need for methanol handling at manufacturing scale

Importantly, this technology complements - not replaces - our established systems, further broadening the solutions we can offer our customers across biopharma, food & feed, industrial biotech, and diagnostics.

Read the full press release here.