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Discover our latest articles and information around Pichia based protein expression
Company Information
UNLOCK PICHIA® Technology
UNLOCK PICHIA® Track Record and Company profile
UNLOCK PICHIA® Methanol-free protein production technology
White Paper
Boosted expression of different VHH antibody formats through application of VALIDOGEN’s UNLOCK PICHIA toolbox
We conducted a series of case studies, demonstrating the yield-enhancing effects of applying different toolbox elements of VALIDOGEN's Pichia pastoris protein expression system known as UNLOCK PICHIA®.
High-level methanol-free phytase production in Pichia pastoris
Case Studies
Case study on methanol-free VHH production in Pichia pastoris
Maximizing product titer and space-time yield
Explore our latest two case studies showcasing the power of our methanol-free Pichia protein production technology. By leveraging our unique UNLOCK PICHIA® platform, we have developed optimized, scalable solutions for high-yield methanol-free protein production suitable for commercial manufacturing
Case study on methanol-induced VHH production in Pichia pastoris
Case Study III: Learn how VALIDOGEN's extensive strain and process development achieved an impressive 31 g/L productivity for production of a bivalent VHH.
Editorials
Pichia Protein Production
Check out our latest article on Pichia protein production, featured in the European Biotechnology Autumn Edition, Vol. 23, 2024.
Recombinant protein production in Pichia typically relies on AOX1 promoter-driven expression using methanol for induction. However, some companies avoid methanol due to safety concerns or operational demands. VALIDOGEN's unique AOX1 promoter variants enable methanol-free protein production at high space-time yields, offering advantages beyond safety. Latest case studies underscore the strength of this technology.