VALIDOGEN, formerly known as VTU Technology, is a leading Austrian contract research and development company. VALIDOGEN offers UNLOCK PICHIA - the broadest toolbox and most versatile technology platform available for Pichia pastoris/Komagataella phaffii recombinant peptide/protein production. VALIDOGEN develops high performance expression strains and economically viable peptide/protein production processes for the manufacture of biopharmaceuticals, enzymes, and other recombinant proteins. Founded in 2008, the company emerged to a globally recognized player in the field of Pichia pastoris based peptide/protein expression.


VALIDOGEN’s UNLOCK PICHIA Technology - Productivity through Diversity

Building on Pichia's inherent potential, VALIDOGEN has established an exclusive, yield-enhancing protein production toolbox, advantageous due to its diversity of expression tools and expression strategies. A proprietary AOX1 promoter library combined with a diverse set of platform strains provides the genetic diversity necessary for fine-tuning protein expression. This includes notable 2nd generation promoter variants from VALIDOGEN's exclusive promoter library which offer further process flexibility by facilitating highly productive methanol-free protein expression. Additionally, time-controlled co-expression of helper proteins allows for maximization of protein yields.

VALIDOGEN's unique and high-throughput microscale cultivation and screening abilities, in addition to expertly developed protocols, ensures fast and reliable identification of the best performing genetic arrangement selected from thousands of Pichia strains assessed in parallel.

VALIDOGEN’s UNLOCK PICHIA technology addresses challenges all the way from transcription and translation, to translocation, protein folding, and secretion. This facilitates the expression of more complex proteins and maximizes yield without compromising product quality.



SERVICES -  Recombinant Protein Production Strains and Process Development


VALIDOGEN develops customized high-performance Pichia pastoris production strains in competitive time frames, and offers straightforward bioreactor cultivation, protein purification process development, and optimization services paired with technology transfer and/or protein production. Supporting our customers in product innovation, VALIDOGEN additionally offers fast and reliable engineering and screening of improved enzyme variants.

VALIDOGEN is providing tailor-made solutions to customers from different industry sectors – including pharma, diagnostics, food & feed, chemical, agro and more.