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Learn more about VALIDOGEN's unique secretion strategies at PICHIA 2024

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Modification of the Pichia Secretory Mechanism for Enhanced Productivity
19.03.2024
Aid Atlic, Head of Fermentation Process Development, will provide insights into VALIDOGEN's latest approaches to increase productivity through targeted modification of the Pichia secretion mechanism using new elements from our UNLOCK PICHIA toolbox. Join Aid, our team and the Pichia community at the PICHIA 2024 conference taking place next week. If you can't make it to San Diego, you have the option to attend virtually.

March 25, 2024, 11 a.m. - 11.20 a.m. PST, 8 p.m. - 8.20 p.m. CET
Modification of the Pichia Secretory Mechanism for Enhanced Productivity

One of the major advantages of the Pichia expression host is that the target protein is mostly secreted into the cultivation medium. After cell separation, the product is found in the supernatant, and since no cell disruption is required and very low amounts of cell host proteins are natively secreted, this significantly simplifies the subsequent protein purification. However, the extent to which recombinant proteins are secreted is product-dependent, as not all proteins are produced in high amounts. By modifying the Pichia secretion mechanism using new elements of VALIDOGEN’s UNLOCK PICHIA toolbox, we are able to overcome some drawbacks and bottlenecks and significantly increase the productivity of many target proteins. Examples and case studies will be presented for methanol-induced and methanol-free protein production at various scales, including high-throughput microscale cultivations, microbioreactor system and lab-scale fermenter.

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