aGxxGKr6HwXYZsAB0gn3 Latest insights into UNLOCK PICHIA technology developments
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Don't miss latest insights into UNLOCK PICHIA technology developments
VALIDOGEN to present at PICHIA 2021, online conference, March 24 - April 1
Dr. Aid Atlic 
Senior Scientist Process Development

High cell density cultivations of Pichia pastoris in microbioreactor system
Day 4, March 29, 6.20 p.m. CEST, 09.20 a.m. PDT

 
This talk aims to illustrate the incorporation of a microfermentation system into VALIDOGEN’s strain development program. Microfermentations combine the advantages of microscale cultivations (large number of clones in one batch) with those of bioreactor cultivations (continuous feeding, high cell density and tightly controlled conditions). Multi-gram-per-litre protein titers are obtained with productivities that are predictive for bioreactor cultivations, thereby further leveraging the benefits of UNLOCK PICHIA. Examples and case studies will be presented that show the applications of Pichia high cell density microscale cultivations in strain development and process optimization projects.
Dr. Iskandar Dib
Principal Scientist Process Development and Analytics

Fast track development with Pichia pastoris – meeting the challenges of protein production using UNLOCK PICHIA
Day 6, March 31, 6.40 p.m. CEST, 09.40 a.m. PDT

 
In this end-to-end project for an albumin fusion NBE candidate, Iskandar will take you on a tour through VALIDOGEN’s services, technologies and capabilities along our typical development lines. Starting with initial clone screening and subsequent strain improvement using the UNLOCK PICHIA toolbox, we then performed upstream and downstream process set-up to generate a first purified sample for functionality testing. In a second phase, an improved and fully scalable production process was developed and characterized.
VALIDOGEN is part of BIO-Europe Spring 2021, online conference, March 22-25
If you are interested in learning more about UNLOCK PICHIA, we would be very happy to arrange a digital meeting through the partnering system or just contact us directly. We look forward to connecting with you!
UNLOCK PICHIA advantages 
  • Broadest Pichia platform: numerous expression tools & different strategies for the enhancement of production yields and product quality
  • Targeted debottlenecking for yield maximization
  • Secreted products - beneficial starting point for protein purification
  • Complete absence of methanol through VALIDOGEN´s methanol-free promoters
  • Tailor-made glycoproteins - UNLOCK PICHIA boosting Pichia GlycoSwitch®
  • Stable, robust and scalable processes for commercial manufacturing
Download our latest VHH expression case studies as a white paper
For more information please visit our website or contact us directly:
VALIDOGEN GmbH
Parkring 18, 8074 Raaba-Grambach, Austria
office@validogen.com, T: + 43 316 4009 4000
www.validogen.com
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VALIDOGEN GmbH · Parkring 18 · Raaba-Grambach 8074 · Austria