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UNLOCK PICHIA - Productivity through diversity


13 - Recent Advances In Fermentation Technology,
27 - 30 October, 2019 Ft. Myers, US
Dr. Roland Weis, Head of Operations, VALIDOGEN GmbH
RAFT® 13 - Recent Advances in Fermentation Technology 

“UNLOCK PICHIA - a toolbox to maximize productivity through diversity”
‘Cell factory design and engineering’ session, October 27, 2019 2:00 PM - 4:30 PM

Dr. Weis will show how UNLOCK PICHIA provides an ideal response to an industrial protein production environment in which novel product classes and current trends in protein production demand more versatile and yet robust expression systems.
VALIDOGEN’s answer is a yield-enhancing protein production toolbox known as UNLOCK PICHIA enabling fine-tuning of protein expression by its diversity of molecular tools and expression strategies for Pichia pastoris. Continuous expansion & improvement of VALIDOGEN's technology platform allows for the targeted debottlenecking of protein expression all the way from transcription and translation to translocation, protein folding and secretion thereby facilitating the expression of more complex proteins without compromising product quality.

High-throughput cultivation & screening regime
Selection of best-performing clones from strain engineering approaches in microscale, i.e. 96-deep-well plates, is directly followed by cultivation in benchtop bioreactors to reconfirm screening results and at the same time gather information on growth and production behavior. Subsequent bioreactor cultivation process optimization, elucidating the interplay of important process parameters such as pH-value, temperature, feeding profile as well as biomass level, results in maximization of yield & quality of the target protein.
UNLOCK PICHIA advantages
  • Broadest Pichia platform: numerous expression tools & different strategies for the enhancement of production yields and product quality
  • Record expression level of 35 g/L
  • Secreted target protein - beneficial starting point for protein purification
  • Complete absence of methanol through VALIDOGEN´s methanol-free promoters
  • Stable, robust and scalable processes for commercial manufacturing
Meet VALIDOGEN's team at one of the following events: 

Further events 2019 / 2020:
  • CPhI 2019, 5 - 7 November, Frankfurt, Germany  
  • BIO-Europe 2019, 11 - 13 November, Hamburg, Germany
  • ESIB 2019, 18 - 21 November, Graz, Austria
  • PEPTALK 2020, 20 - 24 January, San Diego, US
Copyright © 2019 VALIDOGEN GmbH, All rights reserved.
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